Aim: To determine the incidence and risk factors of retinopathy of prematurity (ROP) in premature infants referred to a tertiary eye hospital during 2003- 2007 to provide preliminary evidence about ROP in Iran.
Methods: In a cross-sectional study, data of premature infants screened for ROP in Farabi Eye Hospital including possible risk factors and eye exams' results were recorded and analyzed using chi square, univariate and multiple regressions. Sever ROP was defined as ROP needing treatment or stage 4 or 5 of ROP.
Results: Among 953 premature infants, 329 (34.5%) had any stage of ROP. Severe ROP was seen in 22.6% (215/953) of infants (16.5%: treatable, 6.1%: advanced untreatable). The mean GA and BW of infants with severe ROP were 28.8?2.4 weeks and 1256?389 gr respectively. Univariate analysis showed significant relation between GA, BW, oxygen therapy, blood transfusion and ROP (all p values<0.001), while multiple regression methods showed GA, BW and oxygen therapy as independent predictors of ROP (p values <0.001, 0.019 and 0.033 respectively).
Conclusion: We observed a relatively high incidence of ROP in our series especially its severe form affecting relatively more mature infants, which merits further investigation. GA, BW and Oxygen therapy were independent ROP determinants.