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Gamma knife radiosurgery for uveal melanoma: 12 years of experience.
  1. Giulio Modorati (modorati.giulio{at}hsr.it),
  2. Elisabetta Miserocchi (miserocchi.elisabetta{at}hsr.it),
  3. Laura Galli (galli.laura{at}hsr.it),
  4. Piero Picozzi (picozzi.piero{at}hsr.it),
  5. Paolo Rama (rama.paolo{at}hsr.it)
  1. Department of Ophthalmology and Visual Sciences, San Raffaele Hospital, Italy
  2. Department of Ophthalmology and Visual Sciences, San Raffaele Hospital, Italy
  3. Clinic of Infectious Diseases, San Raffaele Hospital, Italy
  4. Departement of Neurosurgery, San Raffaele Hospital, Italy
  5. Department of Ophthalmology and Visual Sciences, San Raffaele Hospital, Italy

    Abstract

    Aim: To present our treatment protocol and evaluate the results of Gamma Knife Radiosurgery (GKR) in treating patients with uveal melanoma.

    Methods: Seventy-eight consecutive patients with uveal melanoma were treated with the stereotactic radiosurgery (radiation dose 30-50 Gy) with Leksell Gamma-Knife at the San Raffaele University Hospital, Milan, Italy between 1994 and 2006. The main outcome measures evaluated were: survival rate, local tumor control, eye retention rate, visual acuity, treatment-related complications.

    Results: Survival rate was 88.8% at 3 years and 81.9% at 5 years. Local tumor control was achieved in 91.0% of patients. The median tumor thickness reduction after treatment was 1.96 mm (p<0.0001) (-33,3%). The eye retention rate was 89.7%. A significant relative reduction of visual acuity was observed during follow-up. The most frequent treatment-related complications were: exudative retinopathy (33.3%), neovascular glaucoma (18.7%), radiogenic retinopathy (13.5%) and vitreous hemorrhages (10.4%).

    Conclusion: GKR can be considered an alternative to enucleation for the treatment of choroidal melanomas.

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