Aim: To present our treatment protocol and evaluate the results of Gamma Knife Radiosurgery (GKR) in treating patients with uveal melanoma.
Methods: Seventy-eight consecutive patients with uveal melanoma were treated with the stereotactic radiosurgery (radiation dose 30-50 Gy) with Leksell Gamma-Knife at the San Raffaele University Hospital, Milan, Italy between 1994 and 2006. The main outcome measures evaluated were: survival rate, local tumor control, eye retention rate, visual acuity, treatment-related complications.
Results: Survival rate was 88.8% at 3 years and 81.9% at 5 years. Local tumor control was achieved in 91.0% of patients. The median tumor thickness reduction after treatment was 1.96 mm (p<0.0001) (-33,3%). The eye retention rate was 89.7%. A significant relative reduction of visual acuity was observed during follow-up. The most frequent treatment-related complications were: exudative retinopathy (33.3%), neovascular glaucoma (18.7%), radiogenic retinopathy (13.5%) and vitreous hemorrhages (10.4%).
Conclusion: GKR can be considered an alternative to enucleation for the treatment of choroidal melanomas.