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A study comparing two protocols of treatment with intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration
  1. LUIS ARIAS (luisarias{at},
  2. Jose M Caminal,
  3. Lidia Casas,
  4. Cristina Masuet,
  5. Maria B Badia,
  6. Marc Rubio,
  7. Octavio Pujol,
  8. Jorge Arruga
  1. Bellvitge university hospital, Spain
  2. Bellvitge university hospital, Spain
  3. Bellvitge university hospital, Spain
  4. Bellvitge university hospital, Spain
  5. Bellvitge university hospital, Spain
  6. Bellvitge university hospital, Spain
  7. Bellvitge university hospital, Spain
  8. Bellvitge university hospital, Spain


    Background: To compare two treatment options for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD): 1) bevacizumab administered once a month for three months and thereafter as needed, (LD: Loading Dose), and 2) bevacizumab administered as needed, after the first injection (PRN: Pro Re Nata).

    Methods: Fifty consecutive patients were enrolled in this prospective study. The first 25 patients were included in the LD group and the last 25 patients in the PRN group. In both groups, the need for retreatment was based on the presence of persistent or recurrent macular edema, subretinal fluid, or pigment epithelial detachment on optical coherence tomography scans.

    Results: At the 6-month follow-up, mean visual acuity improved by 13.7 letters (p<0.001) in the LD group and 4.6 in the PRN group (p<0.001). Thirty-six percent of patients in the LD group compared with 12% in the PRN group gained 15 or more letters (p=0.04). Mean foveal thickness decreased by 91.3 microns (p<0.001) in the LD group and 48.2 in the PRN group (p<0.001). No ocular or systemic side effects were observed.

    Conclusion: Patients with CNV secondary to AMD treated with a LD protocol obtained better results than patients treated with a PRN protocol with intravitreal bevacizumab.

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