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Role of Humphrey-Matrix Frequency Doubling Technology Perimetry threshold strategy in the Early Diagnosis of Retinopathy in Type 1 Diabetes
  1. Mariacristina Parravano (criparra{at}tin.it),
  2. Francesco Oddone (francesco.oddone{at}libero.it),
  3. Davide Mineo,
  4. Marco Centofanti,
  5. Patrizia Borboni,
  6. Renato Lauro,
  7. Lucia Tanga (luciatanga{at}libero.it),
  8. Gianluca Manni (glmanni{at}inwind.it)
  1. Fondazione G.B.Bietti-IRCCS-Rome, Italy
  2. Fondazione G.B.Bietti-IRCCS-Rome, Italy
  3. Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Italy
  4. Dipartimento di Biopatologia e Diagnostica per immagini, Università di Roma Tor Vergata, Italy
  5. Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Italy
  6. Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Italy
  7. Fondazione G.B.Bietti-IRCCS-Rome, Italy
  8. Dipartimento di Biopatologia e Diagnostica per immagini, Università di Roma Tor Vergata, Italy

    Abstract

    Aim: to investigate the role of Humphrey-Matrix threshold testing in the detection of early functional retinal impairment in patients with Diabetes Mellitus type 1 (DM1) without any signs of retinal vasculopathy and to investigate the relationship between both functional and structural retinal parameters and metabolic control.

    Methods: Thirty eyes of 30 DM1 patients, with no sign of retinal vasculopathy, and 30 eyes of 30 age- and sex-matched healthy subjects were enrolled in this cross-sectional clinical study. Functional testing included Humphrey-Matrix Perimetry and White-on-white Humphrey Visual Field Perimetry (HFA), while RNFL thickness was measured by Scanning Laser Polarimetry with variable corneal birefringence compensator (GDx VCC).

    Results: Matrix Mean Deviation (MD) was found to be significantly reduced in DM1 patients compared to controls (-1.10±2.98, 95%CI -2.21, 0.01 vs 1.37±2.11, 95%CI 0.58, 2.16, p=0.0005). HFA MD and Pattern Standard Deviation (PSD) were significantly worse in DM1 patients compared to controls (p=0.010 and p=0.013 respectively). Among structural parameters, average peripapillary RNFL thickness was reduced in DM1 patients (p=0.006). Matrix MD and HFA MD and PSD, average peripapillary and superior Retinal Nerve Fiber Layer (RNFL) were significantly reduced in DM1 patients with HbA1c>7% compared to controls.

    Conclusions: Functional and structural retinal testing by Humphrey-Matrix and GDx VCC could be useful for the identification of early retinal impairment in DM1 patients with no sign of retinal vasculopathy.

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