Aim: To report the functional and morphological outcome of intraocular injection of sodium hyaluronate for treatment of chronic ocular hypotony.
Methods: We reviewed digital chart records of patients with chronic ocular hypotony who had received one or more injections of intravitreal or intracameral sodium hyaluronate (1.4% or 2.3%). The change of the best corrected visual acuity (BCVA) and intraocular pressure (IOP) after treatment were recorded.
Results: Thirty two eyes of 32 patients with a mean age of 56.8 years were analysed. Previous vitreoretinal surgery had been performed on all eyes for either ocular penetrating trauma (6 eyes), chronic uveitis (6 eyes), full macular translocation (5 eyes) and retinal detachment (15 eyes). Mean follow-up after the first intraocular injection was 29.7 months. BCVA (logMAR) at the baseline and the last follow-up visit were 1.84+/-0.65 and 1.82+/-0.72, respectively (p=0.87). The mean IOP at the baseline increased from 2.28+/-0.27 mm Hg to 7.12+/-1.03 mm Hg at the last visit (p<0.001). At the final follow-up, 20 eyes (62.5%) had an IOP higher than 5mmHg and 24 eyes (75%) had an unchanged or improved BCVA.
Conclusions: Stabilization of the IOP and vision in some eyes with chronic ocular hypotony following vitreoretinal surgery can be achieved with intraocular injection of sodium hyaluronate. Large case series and long-term follow-ups are necessary to confirm the beneficial role of intraocular sodium hyaluronate injections in such eyes.