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Activity of antibiotics against Fusarium and Aspergillus
  1. Shelley Day (sday2005{at}gmail.com),
  2. Prajna Lalitha,
  3. Sara Haug,
  4. Annette W Fothergill,
  5. Vicky Cevallos,
  6. Rajendran Vijayakumar,
  7. Namperumalsamy V Prajna,
  8. Nisha R Acharya,
  9. Stephen D McLeod,
  10. Thomas M Lietman (tom.lietman{at}ucsf.edu)
  1. UCSF, United States
  2. Aravind Eye Hospital, India
  3. UCSF, United States
  4. University of Texas Health Sciences Center at San Antonio, United States
  5. UCSF, United States
  6. Aravind Eye Hospital, India
  7. Aravind Eye Hospital, India
  8. UCSF, United States
  9. UCSF, United States
  10. UCSF, United States

    Abstract

    Background/Aims: To study the susceptibility of Fusarium and Aspergillus isolated from keratitis to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin, and benzalkonium chloride (BAK).

    Methods: 10 isolates of Fusarium and 10 isolates of Aspergillus from cases of fungal keratitis at Aravind Eye Hospital in South India were tested using microbroth dilution for susceptibility to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin, and BAK. The minimum inhibitory concentration (MIC) median and 90th percentile were determined.

    Results: BAK had the lowest MIC for both Fusarium and Aspergillus. Chloramphenicol had activity against both Fusarium and Aspergillus, while moxifloxacin and tobramycin had activity against Fusarium but not Aspergillus.

    Conclusions: The susceptibility of Fusarium to tobramycin, moxifloxacin, chloramphenicol, and BAK and of Aspergillus to chloramphenicol and BAK may explain anecdotal reports of fungal ulcers that improved with antibiotic treatment alone. While some of the MICs of antibiotics and BAK are lower than the typically prescribed concentrations, they are not in the range of antifungal agents such as voriconazole, natamycin, and amphotericin B. Antibiotics may, however, have a modest effect on Fusarium and Aspergillus when used as initial treatment prior to identification of the pathologic organism.

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