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Evaluation of ocular manifestations and blindness in HIV/AIDS patients on HAART in a tertiary care hospital in western India
  1. Sanket U Shah (sanket1311{at}yahoo.com),
  2. Sheela P Kerkar (sheelakerkar{at}gmail.com),
  3. Amar R Pazare (arpazare{at}hotmail.com)
  1. Seth GS Medical College and KEM Hospital, India
  2. Seth GS Medical College and KEM Hospital, India
  3. Seth GS Medical College and KEM Hospital, India

    Abstract

    Background: HIV has various ocular manifestations and with the widespread introduction of HAART, their pattern and prevalence is expected to change. Therefore, we evaluated the HIV/AIDS patients on HAART for ocular manifestations and blindness.

    Methods: In this cross-sectional study, 112 HIV-positive patients on HAART presenting to the HIV clinic with CD4 count ≤200 cells/µl were enrolled. The WHO clinical stage, CD4 count, duration of HIV and HAART were recorded. Ocular examination was conducted and prevalence of ocular manifestations and blindness was determined.

    Results: The prevalence of ocular manifestations in HIV/AIDS patients on HAART was 8% (9 out of 112). Seven (6%) of the patients had visual impairment including one patient with blindness. The ocular manifestations included HIV retinopathy (5%), immune recovery uveitis (3%), immune recovery vitritis (3%) and CMV retinitis (2%). The prevalence of ocular manifestations and visual impairment was higher with the CD4 count between 0-100 cells/µl (p=0.002). The prevalence of ocular manifestations was also higher in patients with WHO clinical stages 3 and 4 (p=0.017).

    Conclusions: HAART may be the cause for decline in the prevalence of ocular diseases and visual impairment in HIV/AIDS patients. CD4 count and WHO clinical stage may help predict their occurrence.

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