Article Text

other Versions

Multicentric Malignant Glioma of Adulthood Masquerading as Optic Neuritis
  1. Joseph G Chacko (jchacko{at},
  2. Byron L Lam (blam{at},
  3. Josna Adusumilli (josnaa{at},
  4. Sander R Dubovy (sdubovy{at}
  1. Jones Eye Institute/UAMS, United States
  2. Bascom Palmer Eye Institute, United States
  3. UAMS, United States
  4. University of Miami, United States


    A 48 year-old man presented with typical symptoms and signs of optic neuritis right eye. However, vision deteriorated to no light perception with the development of retinal vascular occlusions despite treatment with intravenous steroids. Serial MRI demonstrated enlarging lesions involving right optic nerve/chiasm, corpus callosum, and cerebellum. A superficial optic nerve biopsy showed atrophy. Cerebellar biopsy revealed the diagnosis of anaplastic astrocytoma (WHO Grade III). The case demonstrates that malignant optic nerve glioma of adulthood may be multicentric in nature and mimic optic neuritis clinically. We recommend a full-thickness optic nerve biopsy to help avoid a false-negative outcome.

    Statistics from

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles