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Twelve-month short-term safety and visual acuity results from a multicentre, prospective study of epiretinal strontium-90 brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularisation secondary to age-related macular degeneration
  1. Marcos P. Ávila (retina{at}cbco.com.br),
  2. Michel Eid Farah,
  3. Arturo Santos,
  4. João Paulo Duprat,
  5. Benjamin W. Woodward,
  6. Jeff Nau (jnau{at}neovistainc.com)
  1. Universidade Federal de Goiás, Brazil
  2. Universidade Federal de São Paulo, Brazil
  3. Universidad de Guadalajara, Mexico
  4. Universidade Federal de São Paulo, Brazil
  5. NeoVista, Inc., United States
  6. NeoVista, Inc., United States

    Abstract

    Background/aims: This study evaluated the short-term safety and feasibility of epiretinal strontium-90 brachytherapy delivered concomitantly with intravitreal bevacizumab for the treatment of subfoveal CNV due to AMD for 12 months. Three-year follow up is planned.

    Methods: In this prospective, nonrandomised, multicentre study, 34 treatment-naïve patients with predominantly classic, minimally classic, and occult subfoveal CNV lesions received a single treatment with 24 Gy beta radiation (strontium-90) and 2 injections of the anti-VEGF antibody bevacizumab. Adverse events were observed. BCVA was measured using standard ETDRS vision charts.

    Results: Twelve months after treatment, no radiation-associated adverse events were observed. In the intent-to-treat (ITT) population, 91% percent of patients lost <3 lines (15 ETDRS letters) of vision at 12 months, 68% improved or maintained their BCVA at 12 months, and 38% gained ≥3 lines. The mean change in BCVA observed at month 12 was a gain of 8.9 letters.

    Conclusion: The safety and efficacy of intraocular, epiretinal brachytherapy delivered concomitantly with anti-VEGF therapy for the treatment of subfoveal CNV secondary to AMD was promising in this small study population. Long-term safety will be assessed for 3 years. This regimen is being evaluated in a large, multicentre, phase III study.

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