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24-hour intraocular pressure control with the travoprost/timolol maleate fixed combination compared with travoprost when both are dosed in the evening in primary open-angle glaucoma
  1. Anastasios G. P. Konstas, MD, PhD (a.konstas{at}prnorb.com),
  2. Dimitrios Mikropoulos MD (d.mikropoulos{at}prnorb.com),
  3. Anna-Bettina Haidich, MSc, PhD (a.haidich{at}prnorb.com),
  4. Kostantinos S. Ntampos MD,
  5. William C. Stewart MD (info{at}prnorb.com)
  1. 1st University, Glaucoma Unit, Dept. of Ophthalmology, Greece
  2. 1st University, Glaucoma Unit, Dept. of Ophthalmology, Greece
  3. Aristotle University, Dept. of Hygiene, Greece
  4. 1st University, Glaucoma Unit, Dept. of Ophthalmology, Greece
  5. University of South Carolina, Carolina Eye Institute, United States

    Abstract

    Objective: To evaluate the 24-hour efficacy and safety of the travoprost/timolol maleate fixed combination (TTFC) versus travoprost when both are dosed in the evening in primary open-angle glaucoma patients.

    Methods: Prospective, double-masked, crossover, active-controlled, randomized 24-hour comparison. After a 6 week medicine-free period, patients were randomized to either TTFC or travoprost for 8 weeks and were then switched to the opposite treatment for another 8 weeks. At the end of the washout and treatment periods a 24-hour pressure curve was performed.

    Results: Thirty-two patients completed the study. The TTFC group demonstrated a lower absolute intraocular pressure levels for the 24-hour curve and at all time points (P¡Ü0.047). The pressure reduction from untreated baseline was significantly different between treatments for all time points (P=0.018). The mean 24-hour pressure fluctuation was lower with TTFC (3.0 mm Hg) compared to travoprost (4.0 mm Hg, P=0.001). No statistical difference existed between the two treatment groups for any adverse event (P>0.05).

    Conclusions: This study suggests that when both drugs are dosed in the evening the TTFC provides improved intraocular pressure reduction over the 24-hour curve and for each individual time point in primary open-angle glaucoma patients.

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