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Predictive index to differentiate invasive squamous cell carcinoma from preinvasive ocular surface lesions by impression cytology
  1. JEISON BARROS (jeisonbarros{at}hotmail.com),
  2. Marcia S Lowen (mlowen{at}globo.com),
  3. Priscilla L Ballalai,
  4. Vera Lucia DM Mascaro,
  5. Jose AP Gomes (japgomes{at}uol.com.br),
  6. Maria Cristina Martins
  1. Federal University of Sao Paulo, Brazil
  2. Federal University of Sao Paulo, Brazil
  3. Federal University of Sao Paulo, Brazil
  4. Federal University of Sao Paulo, Brazil
  5. Federal University of Sao Paulo, Brazil
  6. Federal University of Sao Paulo, Brazil

    Abstract

    Background/aims: On the literature no cytological features have been identified that reliably differentiate invasive squamous cell carcinoma (SCC) from preinvasive lesions in impression cytology (IC) samples. Our aim was to identify cytological features related to malignancy and apply them in a quantitative model to determine an index score with the best predictive power to differentiate SCC from preinvasive ocular surface lesions by IC.

    Methods: 39 patients with ocular surface epithelial lesions were enrolled. IC was obtained from all lesions before surgical excision. Specimens with atypical cells were evaluated regarding 11 cytological parameters based on the 2001 Bethesda system.

    Results: Histopathological diagnosis was pterygium in 1 case, actinic keratosis in 9 cases, intraepithelial neoplasia in 9 cases and SCC in 20 cases. Analysis of the ROC curve revealed that a predictive index score (cut-off point) > or = 4,25 presented the best relationship between sensitivity and specificity in identifying SCC (sensitivity of 95%, specificity of 93%, positive predictive value of 95% and negative predictive value of 93%).

    Conclusion: The scoring system model presented is suitable for clinical practice in differentiating SCC from preinvasive ocular surface lesions by IC and can be better evaluated with prospective use.

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