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Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration
  1. Kayoung Yi (kayoungyi{at}yahoo.co.kr),
  2. Mircea Mujat (mujat{at}psicorp.com),
  3. Boris H Park (hylepark{at}helix.mgh.harvard.edu),
  4. Wei Sun (wsun{at}buphy.bu.edu),
  5. Joan W Miller (joan_miller{at}meei.harvard.edu),
  6. Johanna M Seddon (jseddon{at}earthlink.net),
  7. Lucy H Young (lucy_young{at}meei.harvard.edu),
  8. Johannes F de Boer (jdeboer{at}partners.org),
  9. Teresa C Chen (teresa_chen{at}meei.harvard.edu)
  1. Kangnam Sacred Heart Hospital, Hallym University, Korea, Republic of
  2. Physical Sciences Inc., Andover, Massachusetts, United States
  3. Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts, United States
  4. Boston University, Department of Physics, Boston, Massachusetts, United States
  5. Massachusetts Eye and Ear Infirmary, Retina Service, United States
  6. Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, United States
  7. Massachusetts Eye and Ear Infirmary, Retina Service, United States
  8. Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts, United States
  9. Massachusetts Eye and Ear Infirmary, Glaucoma Service, United States

    Abstract

    Background/Aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomic changes in eyes with non-neovascular age related macular degeneration (AMD) compared to time domain optical coherence tomography (TDOCT).

    Methods: Images were obtained from 3 eyes of 3 patients with AMD using an experimental SDOCT system. Both a Titanium-sapphire (Ti:Sapphire) laser and a superluminescent diode (SLD) was used as a broadband light source to achieve cross-sectional images of the retina. Qualitative and quantitative analysis was done of structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyze drusen size and volume from SDOCT images. TDOCT was done using the fast macular scan (Stratus OCT, Carl Zeiss Meditec, Dublin, CA).

    Results: SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen size, drusen volume, and proportion of drusen.

    Conclusions: With new algorithms to determine drusen size and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve our ability to evaluate structural abnormalities in non-neovascular AMD.

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