Article Text

other Versions

PDF
Pharmacogenetics of Complement Factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab
  1. Aaron Y. Lee (leeaa{at}msnotes.wustl.edu),
  2. Amanda K. Raya (rayaa{at}msnotes.wustl.edu),
  3. Steven M. Kymes (kymes{at}vrcc.wustl.edu),
  4. Alan Shiels (shiels{at}vision.wustl.edu),
  5. Milam A. Brantley, Jr. (brantley{at}vision.wustl.edu)
  1. Washington University School of Medicine, United States
  2. Washington University School of Medicine, United States
  3. Washington University School of Medicine, United States
  4. Washington University School of Medicine, United States
  5. Washington University School of Medicine, Barnes Retina Institute, United States

    Abstract

    Aims: To determine whether complement factor H (CFH) genotypes have a pharmacogenetic effect on the treatment of exudative age-related macular degeneration (AMD) with ranibizumab.

    Methods: A retrospective study of 156 patients with exudative AMD treated with intravitreal ranibizumab monotherapy was conducted. AMD phenotypes were characterized by clinical examination, visual acuity, fundus photography, fluorescein angiography, and injection timing. Patients received intravitreal ranibizumab injections as part of routine ophthalmologic care and were followed for a minimum of nine months. Each patient was genotyped for the single nucleotide polymorphism rs1061170 (Y402H) in the CFH gene.

    Results: Baseline lesion size and angiographic type, as well as mean visual acuities at baseline, 6 months, and 9 months were similar among the three CFH genotypes. Over 9 months, patients with both risk alleles received approximately one more injection (p = 0.09). In a recurrent event analysis, patients homozygous for the CFH Y402H risk allele had a 37% significantly higher risk of requiring additional ranibizumab injections (p = 0.04).

    Conclusions: In our cohort, response to treatment of AMD with ranibizumab differed according to CFH genotype, suggesting that determining patients' CFH genotype may be helpful in the future in tailoring treatment for exudative AMD with intravitreal ranibizumab.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.