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Photoreceptor Status after Anti-vascular Endothelial Growth Factor Therapy In Exudative Age-related Macular Degeneration
  1. Kaori Sayanagi (sayapon123{at},
  2. Sumit Sharma,
  3. Peter K Kaiser (pkkaiser{at}
  1. Cole Eye Institute, United States
  2. Cole Eye Institute, United States
  3. Cole Eye Institute, United States


    Aims: To evaluate the photoreceptor layer status after anti-vascular endothelial growth factor (VEGF) therapy in choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT).

    Design: Prospective, consecutive case series.

    Methods: Twenty-three eyes of 22 patients with CNV secondary to AMD with foveal thickness less than 250 microns after treatment with anti-VEGF therapy and no obvious leakage on time domain OCT, and 8 healthy subjects as controls, were imaged with at least one of four different SD-OCT devices. The inner and outer segment photoreceptor layers (IS/OS) were graded, and correlated with various characteristics including visual acuity.

    Results: The IS/OS layer was detected in 8 eyes (35%) of patients with AMD and all eyes (100%) of the healthy control subjects (p=0.002). Eyes in patients with AMD with preserved IS/OS had significantly better BCVA and mean change in BCVA, and were more likely not to have had previous laser treatment compared to eyes with absent IS/OS.

    Conclusions: SD-OCT is useful tool to visualize IS/OS status. IS/OS is often absent in patients who have received treatment with anti-VEGF therapy for CNV due to AMD. The IS/OS status after anti-VEFG therapy correlates with BCVA and mean change in vision.

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