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Effect of topical atropine on astigmatism
  1. Audrey Chia (wla_chia{at}yahoo.com),
  2. Wei Han Chua (chua.wei.han{at}snec.com.sg),
  3. Donald Tan (snecdt{at}pacific.net.sg)
  1. Singapore National Eye Center, Singapore
  2. Singapore National Eye Center, Singapore
  3. Singapore National Eye Center, Singapore

    Abstract

    Purpose: The aim of this study is to determine if topical atropine, used to retard axial length elongation and myopia progression, has any effect on ocular astigmatism.

    Methods: Data collected from subjects enrolled in the Atropine in the Treatment of Myopia (ATOM) study was analysed. In this study, 400 myopic children (aged 6-12 years) were randomly assigned to administer atropine 1% or a placebo daily to a randomly selected eye for two years. Cycloplegic autorefraction and keratomy readings were measured using a Canon RK5 autorefractor. The refractive error was then split into its power vectors components; J0 and J45.

    Results: Astigmatism increased by 0.12-0.16D per year in both treated and placebo groups. There was no difference between groups (p=0.182). The increase was mirrored by an increase in corneal astigmatism of 0.10-0.13 D per year suggesting that most of the change was corneal in nature. There was an increase in JO vector (ie. with-the-rule astigmatism) with no change in the J45 (oblique) vector over time. The change in the J0 vector was significantly larger in the atropine-treated versus atropine-untreated eyes during the 2 year treatment period (p=0.016) but this difference disappeared after atropine was stopped.

    Conclusion: The use of atropine on a daily basis over two years did not have any clinically significant effect on astigmatism.

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