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The role of PAMP's and DAMP's in the pathogenesis of acute and recurrent anterior uveitis
  1. Denis Wakefield (d.wakefield{at}unsw.edu.au),
  2. Paul Gray (paul.gray2{at}sesiahs.health.nsw.gov.au),
  3. John Chang (jh.chang{at}unsw.edu.au),
  4. Nick Di Girolamo (n.digirolamo{at}unsw.edu.au),
  5. Peter McCluskey (peter.mccluskey{at}swsahs.nsw.gov.au)
  1. University of New South Wales, Australia
  2. University of New South Wales, Australia
  3. University of New South Wales, Australia
  4. University of New South Wales, Australia
  5. University of New South Wales, Australia

    Abstract

    The pathogenesis of acute and recurrent anterior uveitis is poorly understood. Here we present recent evidence for the hypothesis that this disease may be associated with activation of receptors of the innate immune system, such as Toll like receptors (TLR), by pathogen associated molecule patterns (PAMPs), such as lipopolysaccharide (LPS), derived from triggering Gram negative bacteria. Acute anterior uveitis results in ocular tissue damage and the release of endogenous molecules (Damage associated molecular patterns- DAMPs), such as heat shock proteins (HSP) and S100 proteins that can also activate TLRs and thus perpetuate or reactivate intraocular inflammation.

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