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Fundus autofluorescence in subfoveal choroidal neovascularization secondary to pathologic myopia
  1. Maurizio Parodi (maubp{at},
  2. Pierluigi Iacono (pierluigi.iacono{at},
  3. Giuseppe Ravalico
  1. Eye Clinic, Azienda Ospedaliero-Universitaria of Trieste, Italy
  2. Fondazione G. B. Bietti per l’Oftalmologia, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifi, Italy
  3. Eye Clinic, Azienda Ospedaliero-Universitaria of Trieste, Italy


    Purpose: to describe the fundus autofluorescence (FAF) characteristics of choroidal neovascularization (CNV) associated with Pathologic Myopia (PM), and their modification after photodynamic therapy (PDT).

    Design: Open-label, prospective, interventional case series.

    Methods: Forty-two patients affected by subfoveal CNV in PM underwent PDT with a 24-month follow-up. Each patient underwent an ophthalmological examination every three months, including FAF and fluorescein angiography. FAF distribution was qualitatively evaluated at the CNV site, around the CNV and outside the area affected by CNV.

    Results: CNV at baseline showed high FAF signal with uniform distribution, or with some spots of low FAF internally, in 64% and 36% of cases, respectively. At the 3-month control after PDT, the CNV retained the same response, but a round halo of increased signal extending beyond the site of the PDT application was detectable around the CNV. At the end of the follow-up, a high or a low FAF signal was detected in 40% and 60% of cases, respectively.

    Conclusion: CNV secondary to PM shows a specific, high signal, FAF pattern. A round halo of increased FAF signal surrounding the CNV was detectable after PDT application, whereas a FAF signal progressive reduction was visible at and around the CNV site from the sixth month. A high FAF signal at the CNV site is associated with an improved visual acuity outcome at the 2-year follow-up. Further studies to correlate the morphological and functional features are advisable, especially by means of microperimetric analyses and with a longer-term follow-up.

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