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Use of hydroxypropylmethylcellulose 2% for removing adherent silicone oil from silicone intraocular lenses
  1. S Chien Wong (chien22{at}yahoo.com),
  2. Yashin D Ramkissoon,
  3. Mauricio Lopez,
  4. Kristopher Page,
  5. Ivan P Parkin,
  6. Paul M Sullivan
  1. Moorfields Eye Hospital, United Kingdom
  2. Moorfields Eye Hospital, United Kingdom
  3. Moorfields Eye Hospital, United Kingdom
  4. University College London, United Kingdom
  5. University College London, United Kingdom
  6. Moorfields Eye Hospital, United Kingdom

    Abstract

    Background / aims: To investigate the effect of hydroxypropylmethylcellulose (HPMC) on the physical interaction (contact angle) between silicone oil and a silicone intraocular lens (IOL).

    Methods: In vitro experiments were performed, to determine the effect of HPMC (0.5%, 1% or 2%), with or without an additional simple mechanical manoeuvre, on the contact angle of silicone oil at the surface of both silicone and acrylic (control) IOLs. A balanced salt solution chamber was used. The study group comprised of 21 silicone and 9 acrylic IOLs.

    Results: Median contact angle of silicone oil on silicone IOL was 99°. The addition of HPMC 2% alone did not significantly alter contact angle. HPMC 2% combined with an additional single mechanical manoeuvre increased contact angle to 180° (greater non-wetting), with complete separation of silicone oil from silicone IOL within 1 minute. The manoeuvre alone, or in conjunction with a lower concentration of HPMC (0.5 or 1%), was ineffective in increasing the contact angle.

    Conclusion: We present a novel, non-toxic technique of using hydroxypropylmethylcellulose 2% combined with a simple mechanical manoeuvre, for the removal of adherent silicone oil droplets from silicone intraocular lenses.

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