Aim: To evaluate a new approach of re-canalization of nasolacrimal duct obstruction (RC-NLDO) in the treatment of the nasolacrimal duct obstruction (NLDO) and chronic dacryocystitis.
Methods: 583 patients with 641 eyes suffering from NLDO and chronic dacryocystitis were enrolled in this study. The RC-NLDO was performed in 506 eyes, with 135 eyes underwent external dacryocystorhinostomy (EX-DCR) as controls. Patient follow-up for 54 months was evaluated by symptoms, dye disappearance test, lacrimal irrigation and digital subtraction dacryocystogram. The RC-NLDO was also performed in 12 rhesus monkeys for histopathological examination.
Results: The clinical success rats were 93.1% in 506 cases of RC-NLDO, and 91.11% in 135 cases of EX-DCR. The success rats for second surgery were achieved in 85.19% on RC-NLDO and 40.0% on EX-DCR. No major intra- or post-operative complications were observed in the RC-NLDO group. The mean operative duration was 12.5 minutes for RC-NLDO while 40.3 minutes for EX-DCR (P<0.001). Pathological study in rhesus monkeys demonstrated that the RC-NLDO wounded epithelium in nasolacrimal duct healed completely within 1 month without granulation tissue formation.
Conclusion: Our findings demonstrated that the RC-NLDO was a simple and effective approach proven to re-canalize the obstructed nasolacrimal duct with a comparable success rate to EX-DCR.