A 42-year-old woman was diagnosed with both Fuchs heterochromic uveitis (FHU) and ocular toxoplasmosis. She developed severe glaucoma and underwent trabeculectomy. In the perioperatieve period, she was treated with pyrimethamine and foline acid. Aqueous humour was collected and examined for rubella virus and Toxoplasma gondii by Goldmann-Witmer coefficient (GWC) and PCR. PCR results were negative, however, GWC values were positive (>3) for both pathogens. After 17 months cataract surgery was performed. By then the GWC for T. gondii had become negative, but the GWC for rubella virus was still positive.
The present case highlights the clinical and laboratory diagnosis of FHU and ocular toxoplasmosis. It also demonstrates the existence of two uveitis entities, FHU and Toxoplasmosis, in a single patient.