Background/aims: To examine the association between self-reported diabetes and early or late age-related macular degeneration (AMD) in the European population.
Methods: The Eureye is a multi-center cross-sectional population-based study. Participants aged 65 years and over underwent an eye examination including digital retinal photography. The images were graded at a single center according to the modified International Classification System for AMD. A structured questionnaire was administered by trained fieldworkers for putative risk factors for AMD including history of diabetes mellitus. Logistic regression models were used to examine the association between diabetes and stages of AMD, taking account of potential demographic, behavioral, dietary, and medical confounders.
Results: Data on diabetes history and potential confounders were available in 2117 controls subjects without AMD, 2182 with early AMD, 49 with GA, and 101 with NV-AMD. After adjusting for potential confounders, subjects with neovascular AMD compared to controls had increased odds for diabetes (odds ratio 1.81; 95% confidence interval, 1.10-2.98, p=0.02), while subjects with AMD grades 1-3 or GA had not.
Conclusion: In the EUREYE study positive association of self-reported diabetes mellitus with neovascular AMD was found. The hypothesis that diabetes is associated with neovascular AMD but not with geographic atrophy may suggest different pathogenesis of the two advanced forms of the disease and needs to be further evaluated.