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Association of Self-reported Diabetes with Age-related Macular Degeneration in the EUREYE study
  1. Fotis Topouzis (ftopouzis{at}otenet.gr),
  2. Eleftherios Anastasopoulos,
  3. Cristina A Augood,
  4. Graham C Bentham,
  5. Usha Chakravarthy,
  6. Paulus T V M de Jong,
  7. Mati Rahu,
  8. Johan Seland,
  9. Gisele Soubrane,
  10. Laura Tomazzoli,
  11. Johannes R Vingerling,
  12. Jesus Vioque,
  13. Ian S Young,
  14. Astrid E Fletcher
  1. Department of Ophthalmology, Aristotle University of Thessaloniki, Greece
  2. Department of Ophthalmology, Aristotle University of Thessaloniki, Greece
  3. Department of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, United Kingdom
  4. Centre for Environmental Risk, University of East Anglia, United Kingdom
  5. Department of Ophthalmogy, Queen's University of Belfast, United Kingdom
  6. The Netherlands Ophthalmic Research Institute, Academic Medical Centre Amsterdam, Netherlands
  7. Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallin, Estonia
  8. Øyeavdelingen, Haukeland Sykehus University of Bergen, Norway
  9. Clinique Ophtalmologique, Universitaire De Creteil, Paris, France
  10. Clinica Oculistica, Università degli Studi di Verona, Italy
  11. The Netherlands Ophthalmic Research Institute, Academic Medical Centre Amsterdam, Netherlands
  12. Dpto. Salud Publica Universidad Miguel Hernández, Alicante,,Ciber de Epidemiología y Salud Pública, Spain
  13. Centre for Clinical and Population Sciences, Queen’s University of Belfast, United Kingdom
  14. Department of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, United Kingdom

    Abstract

    Background/aims: To examine the association between self-reported diabetes and early or late age-related macular degeneration (AMD) in the European population.

    Methods: The Eureye is a multi-center cross-sectional population-based study. Participants aged 65 years and over underwent an eye examination including digital retinal photography. The images were graded at a single center according to the modified International Classification System for AMD. A structured questionnaire was administered by trained fieldworkers for putative risk factors for AMD including history of diabetes mellitus. Logistic regression models were used to examine the association between diabetes and stages of AMD, taking account of potential demographic, behavioral, dietary, and medical confounders.

    Results: Data on diabetes history and potential confounders were available in 2117 controls subjects without AMD, 2182 with early AMD, 49 with GA, and 101 with NV-AMD. After adjusting for potential confounders, subjects with neovascular AMD compared to controls had increased odds for diabetes (odds ratio 1.81; 95% confidence interval, 1.10-2.98, p=0.02), while subjects with AMD grades 1-3 or GA had not.

    Conclusion: In the EUREYE study positive association of self-reported diabetes mellitus with neovascular AMD was found. The hypothesis that diabetes is associated with neovascular AMD but not with geographic atrophy may suggest different pathogenesis of the two advanced forms of the disease and needs to be further evaluated.

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