Article Text

other Versions

PDF
Long-term survival of uveal melanoma patients after surgery for liver metastases
  1. Shahar Frenkel (shahar.frenkel{at}gmail.com),
  2. Itzhak Nir (itzhaknir{at}yahoo.com),
  3. Karen Hendler (kech_hen{at}yahoo.com),
  4. Michal Lotem (mlotem{at}hadassah.org.il),
  5. Ahmed Eid (rahmed{at}hadassah.org.il),
  6. Oded Jurim (ojurim{at}yahoo.com),
  7. Jacob Pe’er (peer{at}hadassah.org.il)
  1. Hadassah-Hebrew University Medical Center, Israel
  2. Hadassah-Hebrew University Medical Center, Israel
  3. Hadassah-Hebrew University Medical Center, Israel
  4. Hadassah-Hebrew University Medical Center, Israel
  5. Hadassah-Hebrew University Medical Center, Israel
  6. Hadassah-Hebrew University Medical Center, Israel
  7. Hadassah-Hebrew University Medical Center, Israel

    Abstract

    Aims: To evaluate the post-hepatectomy survival of uveal melanoma patients with liver metastases.

    Methods: Data were collected from the files in the Departments of Ophthalmology, General Surgery and Oncology, for uveal melanoma patients who were seen in the Ocular Oncology Clinic at the Hadassah Medical Center from 1988 to 2007. Statistical analysis was performed using JMP statistical software (SAS Institute, Cary, NC).

    Results: Of the 558 patients, 74 (13.3%) developed metastases after a median of 35.0 months from the initial diagnosis. Thirty-five patients underwent hepatectomy. These patients had similar clinical characteristics as those who did not undergo hepatectomy. The median survival time from the detection of metastasis was 3.7-fold higher in the operated patients in comparison with the non-operated patients. Post-hepatectomy survival of patients who were found in surgery to have 1-5 metastatic nodules was 3.1 times longer than those with 6 or more lesions. The hepatectomies of 13 patients resulted in complete resection of the hepatic metastases with clean histologic margins (R0). These patients survived 1.9 times longer than those with residual disease (R1/R2).

    Conclusion: It is possible to significantly extend the life expectancy of uveal melanoma patients who develop isolated hepatic metastases by complete resection of the lesions.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles

    • At a glance
      Harminder S Dua Arun D Singh