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Retinal Nerve Fiber Layer Thickness Measurement Reproducibility Improved with Spectral Domain Optical Coherence Tomography
  1. Jong S Kim (kimj3{at}upmc.edu),
  2. Hiroshi Ishikawa (ishikawah{at}upmc.edu),
  3. Kyung R Sung (sungeye{at}gmail.com),
  4. Juan A Xu (xuj3{at}upmc.edu),
  5. Gadi Wollstein (wollsteing{at}upmc.edu),
  6. Richard A Bilonick (bilonickra{at}upmc.edu),
  7. Michelle L Gabriele (gabrieleml{at}upmc.edu),
  8. Larry Kagemann (kagemannl{at}upmc.edu),
  9. Jay S Duker (jduker{at}tuftsmedicalcenter.org),
  10. James G Fujimoto (jgfuji{at}mit.edu),
  11. Joel S Schuman (schumanjs{at}upmc.edu)
  1. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  2. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  3. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  4. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  5. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  6. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  7. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  8. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States
  9. New England Eye Center, Tufts Medical Center, Boston, MA, United States
  10. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, MA, United States
  11. UPMC Eye Center, Eye and Ear Inst, Ophthalmol and Vis Sci Res Center, Dept Ophtalmol, Univ Pittsburg, United States

    Abstract

    Background/aims: To investigate retinal nerve fiber layer (RNFL) thickness measurement reproducibility using conventional time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT), and to evaluate two methods defining the optic nerve head (ONH) centering: centered each time (CET) vs. centered once (CO), in terms of RNFL thickness measurement variability on SD-OCT.

    Methods: Twenty-seven eyes (14 healthy subjects) had 3 circumpapillary scans with TD-OCT and 3 raster scans (three-dimensional or 3D image data) around ONH with SD-OCT. SD-OCT images were analyzed in two ways: 1) CET: ONH center was defined on each image separately, and 2) CO: ONH center was defined on one image and exported to other images after scan registration. After defining the ONH center, a 3.4mm diameter virtual circular OCT was re-sampled on SD-OCT images to mimic the conventional circumpapillary RNFL thickness measurements taken with TD-OCT.

    Results: CET and CO showed statistically significantly better reproducibility than TD-OCT except for 11:00 with CET. CET and CO methods showed similar reproducibility.

    Conclusions: SD-OCT 3D cube data generally showed better RNFL measurement reproducibility than TD-OCT in this healthy cohort. The choice of ONH centering methods did not affect RNFL measurement reproducibility.

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