Purpose: To report the diagnostic capability of macular parameters in early glaucoma.
Material and methods: In a Cross-sectional observational study, two groups of subjects (early glaucoma and normals) who satisfied the inclusion and exclusion criteria were recruited. The diagnosis of early glaucoma was based on a glaucomatous appearance of the optic disc correlating with visual field defects (fulfilling at least two of three Anderson and Patella's criteria, with Mean Deviation less than or equal to - 6 dB (decibels). Normals had normal optic disc and fields with intraocular pressure < 22 mm Hg. All patients underwent a complete ophthalmic evaluation including visual field examination (24-2 / 30-2 SITA standard program) and imaging with Stratus OCT 3. Sensitivity, specificity, area under receiving operating characteristic curve (AUROC) and likelihood ratio were calculated for various macular parameters.
Results: 56 eyes (56 patients) with early glaucoma and 75 eyes (75 normals) were analysed. Both outer inferior average volume (p = 0.003) and thickness parameters (p=0.002) were statistically significantly lower in the glaucoma group. Outer inferior average volume had a “best combination” of sensitivity and specificity (56% and 79% respectively). Both outer inferior average volume and thickness parameters yielded the best AUROC’s of 0.66.
Conclusions: Outer inferior macular thickness and volume parameters in early glaucoma are significantly different from normals. The moderate sensitivity and specificity suggests that role of macular parameters in the diagnosis of early glaucoma is limited.