Article Text

other Versions

PDF
The genetics of central corneal thickness
  1. David P Dimasi (david.dimasi{at}flinders.edu.au),
  2. Kathryn P Burdon (kathryn.burdon{at}flinders.edu.au),
  3. Jamie E Craig (dima0017{at}flinders.edu.au)
  1. Flinders University of South Australia, Australia
  2. Flinders University of South Australia, Australia
  3. Flinders University of South Australia, Australia

    Abstract

    Evidence in the recent literature has highlighted the importance of central corneal thickness (CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has been identified as a risk factor for open-angle glaucoma. Despite having an extensive knowledge of the structure and function of the cornea, little is known about the pathways that determine CCT. There is data to suggest however, that CCT has a strong genetic component. Heritability studies conducted in twins and family pedigrees indicate that CCT is one of the most highly heritable human traits, whilst data from a diverse range of ethnic groups shows clear ethnic-related differences in CCT. Extreme CCT measurements have also been associated with rare genetic diseases. Whilst there is strong evidence supporting a genetic component to normal CCT variation, to date, no genes have been identified. This review investigates the current literature surrounding this topic and explores the significance of understanding the genetics of CCT and how this might benefit the field of open-angle glaucoma treatment and research.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.