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No association of CTLA-4 polymorphisms with susceptibility to Behcet's disease
  1. Liping Du (dulplab{at},
  2. Peizeng Yang (peizengy{at},
  3. Shengping Hou (sphou828{at},
  4. Hongyan Zhou (hyz010203{at},
  5. Aize Kijlstra
  1. Chongqing Key Laboratory of Ophthalmology, China
  2. Chongqing Key Laboratory of Ophthalmology, China
  3. Chongqing Key Laboratory of Ophthalmology, China
  4. Zhongshan Ophthalmic Center, China
  5. Eye Research Institute Maastricht, Department of Ophthalmology, Netherlands


    Background: Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of T lymphocytes and has been shown to be associated with a number of autoimmune diseases. The present study was performed to assess the association between CTLA-4 polymorphisms and Behcet's disease (BD) in Chinese patients.

    Methods: Two hundred and twenty eight BD patients and 207 controls were analyzed for 4 SNPs (-1661A/G, -318C/T, +49G/A, and CT60G/A) in the CTLA-4 gene by PCR-restriction fragment length polymorphism (RFLP) analysis. The association between SNP +49A/G and BD in Chinese population as well as other ethnic groups was analyzed by meta-analysis.

    Results: No association could be detected between CTLA-4 SNPs or haplotypes and BD. Also no association was observed between CTLA-4 polymorphisms and BD sub-groups, stratified by clinical features. A meta-analysis showed that there was no heterogeneity between studies (p=0.60, I2=0%) and that CTLA-4 SNP +49 was not associated with BD (overall effect: Z=0.26, p=0.79).

    Conclusion: Our study and a meta-analysis failed to demonstrate an association between the tested CTLA-4 polymorphisms and BD.

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