Aim: To compare the long-term intraocular pressure (IOP) outcomes of Ahmed Glaucoma Valve (AGV) implantation to trabeculectomy with mitomycin C (MMC) in open-angle glaucoma (OAG).
Methods: 78 OAG patients who underwent AGV implantation were matched with respect to age, preoperative surgery, preoperative IOP, and preoperative medicines to 88 OAG patients who underwent trabeculectomy with MMC with a minimum of 3 years follow-up. The cumulative probability of success between the two groups with different criteria were analyzed: A) an IOP < 21 mmHg and a reduction of IOP > 15% from baseline; and B) an IOP < 18 mmHg and a reduction of IOP > 20% from baseline. No loss of light perception, no additional glaucoma surgery, and no hypotony were also required.
Results: The 5-year cumulative probability of success was not statistically significant between eyes that had an AGV or trabeculectomy with MMC when success was defined as criteria A (P = 0.094). However, when success was defined according to criteria B, eyes undergoing trabeculectomy with MMC had a higher rate of success (P = 0.024).
Conclusions: Trabeculectomy with MMC has a significantly higher 5-year cumulative probability of success compared to AGV implants when greater reduction IOP is necessary.