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Accuracy of Retinal Thickness Measurements obtained with Cirrus Optical Coherence Tomography
  1. Pearse A Keane (pearsek{at}gmail.com),
  2. Paramdeep S Mand (paramdeep.mand{at}gmail.com),
  3. Sandra Liakopoulos (sandra.liakopoulos{at}uk-koeln.de),
  4. Alexander C Walsh (awalsh{at}doheny.org),
  5. Srinivas R Sadda (sadda{at}usc.edu)
  1. Doheny Eye Institute, United States
  2. David Geffen School of Medicine, United States
  3. University of Cologne, Germany
  4. Doheny Eye Institute, United States
  5. Doheny Eye Institute, United States

    Abstract

    Aim: To report the frequency and severity of retinal thickness measurement errors in a Fourier domain optical coherence tomography (FDOCT) device, Cirrus OCT.

    Methods: Data from 209 eyes undergoing Cirrus OCT imaging with the Macular Cube protocol were collected. For each eye, the position of the automated retinal boundary lines used by the Cirrus OCT software for thickness calculations was assessed using a 6-point categorical scale. The presence of errors was correlated with various parameters including: retinal morphologic features and disease diagnosis.

    Results: Errors of retinal boundary detection were observed in 57.5% of eyes, but were severe in only 9.6% of eyes. The identification of subretinal fluid, subretinal tissue, pigment epithelium detachment, or a diagnosis of choroidal neovascularization, was associated with more severe errors. Retinal cysts, or a diagnosis of retinal vascular disease were less likely to be associated with significant error.

    Conclusions: Retinal thickness measurement errors appear to occur less frequently with Fourier domain OCT (Cirrus OCT), but segmentation errors remain a concern, particularly in assessment of eyes with structurally complex retinal disease. With the recent release of multiple FDOCT systems, assessment of segmentation error may be an important factor in determining the relative clinical merits of these systems.

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