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Basic parameters of thrombophilia in ocular behçet's disease with posterior segment involvement
  1. Mehmet Citirik1,
  2. Ibrahim C Haznedaroglu2,
  3. Kuddusi Teberik1,
  4. Emel Soykan1 and
  5. Orhan Zilelioglu1
  1. 1 SB Ankara Ulucanlar Eye Education and Research Hospital, Turkey;
  2. 2 Hacettepe University Faculty of Medicine Department of Hematology, Turkey
  1. * Corresponding author; email: mcitirik{at}hotmail.com

Abstract

Purpose: To assess basic thrombophilic parameters in both active and inactive periods of the ocular Behçet’s disease (BD) with posterior segment involvement in comparison to those in healthy adults as controls.

Method: Thirty patients within the active period of the ocular BD with posterior segment involvement, 30 patients within the inactive period of the ocular BD with posterior segment involvement and 30 age-and sex-matched healthy controls were included into the study. Plasma protein C, free protein S, antithrombin III, and activated protein C resistance were measured in the studied groups.

Results: Activated protein C resistance and antithrombin III levels were significantly altered in both active and inactive ocular BD patients when compared to those in the controls (P< 0.05), whereas protein C and free protein S levels were not significantly changed within both groups (P> 0.05). There was no difference among the active and inactive groups of BD for all of the studied blood tests (P> 0.05).

Conclusion: Activated protein C resistance together with increased antithrombin III plasma levels are associated with the posterior segment involvement in ocular BD based on the assessment of basic thrombophilic tests.

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