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Low prevalence of juvenile-onset Behcet's diease with uveitis in East/South Asian people
  1. Nobuyoshi Kitaichi1,
  2. Akiko Miyazaki1,
  3. Miles R Stanford2,
  4. Daiju Iwata1,
  5. Hormoz Chams3,
  6. Shigeaki Ohno1
  1. 1 Hokkaido University Graduate School of Medicine, Japan;
  2. 2 King's College London, Japan;
  3. 3 Behçet’s Research Center, Shariati Hospital, Teheran University for Medical Sciences, United Kingdom
  1. * Corresponding author; email: nobukita{at}med.hokudai.ac.jp

Abstract

Purpose: There is little information on the demographic and clinical characteristics of Behcet's disease in children in different parts of the world. We sought to provide this information through a questionnaire survey of specialist eye centres.

Methods: Descriptive questionnaires were collected from 25 eye centers in 14 countries. The questionnaire surveyed details of juvenile-onset Behcet's disease with uveitis. Ethnic groups, clinical features, treatments, and prognosis of pediatric-age Behcet's disease were examined on a world scale.

Results: The clinical data of 135 juvenile-onset and 1,227 adult-onset patients with uveitis were collected. The average age of disease diagnosis in the children was 11.7 years old. Of the ethnic groups identified: 54% were from Middle East, 43% from Europe, but only 2% from East/South Asian countries. By contrast, 19.2% of adult patients were from East or South Asia. The frequency of genital ulcers in juvenile patients was 38.7%, which was significantly lower than in adult cases (53.5%; P<0.01).

Conclusions: Behcet's disease with uveitis was less common in children than in adults in East/South Asia. Although the clinical features of the systemic disease were similar between children and adults, there was a lower frequency of genital ulceration in children.

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