Aims: To determine whether edaravone (MCI-186), a free radical scavenger, can reduce the macular edema and improve the visual acuity after arteriovenous sheathotomy in eyes with a branch retinal vein occlusion (BRVO).
Methods: Forty-seven eyes of 47 consecutive patients with a BRVO who were treated with arteriovenous sheathotomy were analyzed. The patients were assigned prospectively to either Group R who received 30 mg of edaravone (Radicut®) systemically during the vitrectomy, or Group N who did not receive any drugs. The postoperative visual acuity was measured before and 12 months after the operation.
Results: At 12 month postoperatively, the best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (logMAR) units improved significantly from 0.22 to 0.56 logMAR units in Group R and from 0.20 to 0.27 units in Group N (P = 0.016). Twenty-three of 27 cases (85%) in Group R and 4 of 15 cases (27%) in Group N showed an improvement in BCVA of >0.2 logMAR units (P = 0.0025).
Conclusion: The better visual acuity in patients given edaravone than those without endaravone during the arteriovenous sheathotomy suggests that edaravone improved the physiology of the retinal cells after the arteriovenous sheathotomy.
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