Objective: To compare the optical coherence tomography (OCT) features of acute central serous chorioretinopathy (CSC) versus exudative age-related macular degeneration (AMD), and to determine if OCT features can distinguish between these two entities.
Methods: A retrospective, observational study of 50 eyes with CSC and 50 eyes with exudative AMD. Five millimeter Stratus OCT line scans were reviewed for presence of subretinal/intraretinal fluid and retinal pigment epithelium detachment. The height of the fluid and detachments were measured using the OCT manual calipers, and the morphology of the highly reflective line was described.
Results: Intraretinal fluid (IRF), pigment epithelial detachment (PED), irregularities, thickening, and attenuation of the highly reflective line were more often associated with AMD. When present, the PED was significantly greater in AMD than CSC. Patients with CSC were more likely to have subretinal fluid (SRF), and when present, the SRF height was significantly greater in CSC. CSC patients also had more hypertrophic outer retinal changes (HORC) on OCT compared to AMD.
Conclusion: Exudative AMD and acute CSC have distinguishing features on OCT that may help clinicians to accurately differentiate between the two conditions using OCT primarily.