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Confocal Microscopy Study of Donor-Recipient Interface Following Descemet’s Stripping with Endothelial Keratoplasty
  1. Edgar Espana*,
  2. Bo Huang
  1. University of Mississippi Medical Center, United States
  1. Correspondence to: , ; eespana{at}


Aim: To evaluate the invivo confocal microscopic corneal features seen in patients that underwent Descemet’s Stripping with Endothelial Keratoplasty (DSEK) and to correlate these findings with the postoperative best spectacle corrected visual acuity (BSCVA) obtained at the time of confocal microscopy.

Methods: Observational case series. A review of charts and confocal microscopy images and videos (Confoscan 4™) of twenty five consecutive eyes from 21 patients who underwent DSEK for Fuchs’ dystrophy or pseudophakic bullous keratopathy and had a follow-up of at least 6 months post-DSEK. Time from DSEK to confocal microscopy ranged from 6 to 22 months. Subepithelial haze, donor-recipient interface haze, interface birefringent particles, presence of stromal folds were evaluated by a blinded observer and correlated to the postoperative BSCVA.

Results: Twenty five eyes (21 patients) with a mean age of 71.3 ± 11.8 years were included. A significant negative correlation was found between postoperative BSCVA and subepithelial corneal haze (Spearman correlation coefficient) [rs] = -0.651; p=0.0004. Donor-recipient interface haze [rs] = -0.0908; p=0.6658, interface particles [rs] = -0.2403; p=0.2472, or the presence of stromal folds [rs] = 0.111; p=0.6055; did not correlate with BSCVA.

Conclusion: Subepithelial haze, donor-recipient stromal interface haze, birefringent particles and stromal folds were present at different degrees in all patients that underwent DSEK. However, subepithelial haze was the only factor that correlated to postoperative BSCVA.

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