Aims: To assess the test-retest variability of intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements utilizing Dynamic Contour Tonometry (DCT) and to evaluate possible influential factors.
Methods: The study included 350 consecutive subjects (175 glaucoma, 175 control; one eye per subject) from 7 European centers. IOP was measured once by Goldmann applanation tonometer (GAT) and twice by DCT (DCT1, DCT2) in a randomized sequence. OPA was also recorded for both DCT measurements. Differences (DCT1-DCT2; OPA1-OPA2; GAT-DCT1; GAT-DCT2) were assessed using the t-test. Intraclass coefficient of correlation (ICC) and coefficient of variation (CoV) for DCT and OPA were calculated.
Results: DCT1 was 0.6±1.6 mmHg higher than DCT2 (P<0.001); OPA1 was 0.1±0.7 mmHg higher than OPA2 (P=0.02). Results were not influenced by randomization test order. In both glaucoma and normal subjects, DCT and OPA showed ICC>0.90 and >0.76, and CoV=4.8-5.0% and 10.3-10.5%, respectively. DCT1 and 2 were respectively 2.4±2.6 and 1.8±2.6 mmHg higher than GAT (P<0.001).
Discussion: DCT test-retest variability was almost perfect for IOP and good for OPA. Tonometry measurements with DCT tended to be overestimated compared to GAT.
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