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Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt-Koyanagi-Harada disease
  1. Shuhong Jiang,
  2. Xialin Liu,
  3. Lixia Luo,
  4. Bo Qu,
  5. Xiangkun Huang,
  6. Li Xu,
  7. Ying Lin,
  8. Shaobi Ye,
  9. Yizhi Liu*
  1. 1 Zhongshan Ophthalmic Center, Sun-Yat-Sen University Guangzhou, China
  1. Correspondence to: Yizhi Liu, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, China; yizhi_liu{at}yahoo.cn

Abstract

Purpose: Patients with VogtïCKoyanagiï CHarada (VKH) disease are known to have severe inflammation after cataract surgery. This study was designed to investigate the role of Interleukin-17-producing T helper (Th17) cell-related pro-inflammatory cytokines on postoperative inflammation in VKH patients.

Methods: Serum from 9 VKH patients and 9 controls with age-related or congenital cataract, was collected before and 1, 7, 30, and 90 days after surgery, and aqueous humor (AqH) at commencement of surgery. Protein levels of IL-23, IL-27, IL-17 and IFN-γ in serum and AqH were measured by ELISA. Laser flare-cell photometer was used to quantify intraocular inflammation.

Results: Serum IL-23 levels were significantly increased in VKH vs. control patients and peaked at 1 day postoperative, decreased rapidly in the first week, then attenuated gradully. In VKH patients, serum levels of IFN-γ were elevated in the first week after surgery and IL-27 was upregulated in the first month. Importantly, serum IL-23 levels were strongly correlated with aqueous flare value (r = 0.689; P = 0.007) and cell counts (r = 0.671; P = 0.01) in VKH vs. control patients.

Conclusions: Our data indicate that serum IL-23 levels are significantly elevated in VKH vs. control patients and strongly associated with postoperative intraocular inflammation.

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