Aims: To compare the ability to detect cystoid macular edema (CME) and its late complications between Spectral Domain Optical Coherence Tomography (SD-OCT) and Fluorescein Angiography (FA).
Methods: Retrospective, observational, case series. 85 eyes who had FA and SD-OCT performed on the same day at first visit and/or at follow-up visits were included. FA and SD-OCT images were evaluated for the evidences associated with CME and other structural changes of macula. FA and SD-OCT images were then superimposed to determine the relationships of diagnostic features between the two images. Main outcome measure was the correlation between FA and SD-OCT findings of macula in patients with CME.
Results: The common causes of CME in our study were retinal vein occlusion (RVO, 63%), diabetic retinopathy (DR, 21.18%) and posterior uveitis (3.53%). CME associated with RVO, AMD and DR were missed by FA in 18.52%, 33.33% and 33.33% of cases respectively. Subretinal fluid was undetectable by FA in 54.55% which mainly were in RVO group. SD-OCT gave earlier CME diagnosis than FA in 3 eyes (3.53%). Residual CME at follow-up visits were missed by FA in 1 eye (1.18%). Late complications of long standing CME (secondary MH (2 eyes), secondary SRF (5 eyes), RPED (1 eye) and photoreceptor atrophy (1 eye)) were detectable only by SD-OCT.
Conclusions: SD-OCT demonstrated greater sensitivity than FA in detecting CME, particularly those associated with RVO, DR and AMD. SD-OCT was also more sensitive than FA for detecting SRF and late complications of long standing CME.
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