Article Text

other Versions

Correlation between Fluorescein Angiography and Spectral Domain Optical Coherence Tomography in the Diagnosis of Cystoid Macular Edema
  1. Teerapat Jittpoonkuson1,*,
  2. Patricia Garcia2,
  3. Richard B. Rosen2
  1. 1 Retina Service, Department of Ophthalmology, BMA General Hospital, Bangkok, Thailand;
  2. 2 Retina Center, The New York Eye and Ear Infirmary, New York, United States
  1. Correspondence to: Teerapat Jittpoonkuson, Ophthalmology, Retina Service, BMA General Hospital Bangkok Thailand, 214/5 Moo 4, Sinbodi Park 4 Village, Soi PrachaUtid 72, PrachaUtid Road, Thungkru District, Bangkok, 10140, Thailand; dr.teerapat{at}


Aims: To compare the ability to detect cystoid macular edema (CME) and its late complications between Spectral Domain Optical Coherence Tomography (SD-OCT) and Fluorescein Angiography (FA).

Methods: Retrospective, observational, case series. 85 eyes who had FA and SD-OCT performed on the same day at first visit and/or at follow-up visits were included. FA and SD-OCT images were evaluated for the evidences associated with CME and other structural changes of macula. FA and SD-OCT images were then superimposed to determine the relationships of diagnostic features between the two images. Main outcome measure was the correlation between FA and SD-OCT findings of macula in patients with CME.

Results: The common causes of CME in our study were retinal vein occlusion (RVO, 63%), diabetic retinopathy (DR, 21.18%) and posterior uveitis (3.53%). CME associated with RVO, AMD and DR were missed by FA in 18.52%, 33.33% and 33.33% of cases respectively. Subretinal fluid was undetectable by FA in 54.55% which mainly were in RVO group. SD-OCT gave earlier CME diagnosis than FA in 3 eyes (3.53%). Residual CME at follow-up visits were missed by FA in 1 eye (1.18%). Late complications of long standing CME (secondary MH (2 eyes), secondary SRF (5 eyes), RPED (1 eye) and photoreceptor atrophy (1 eye)) were detectable only by SD-OCT.

Conclusions: SD-OCT demonstrated greater sensitivity than FA in detecting CME, particularly those associated with RVO, DR and AMD. SD-OCT was also more sensitive than FA for detecting SRF and late complications of long standing CME.

Statistics from


    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles

    • At a glance
      Harminder S Dua Arun D Singh