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Treatment options for iris and anterior ciliary body melanoma include local resection, plaque radiation therapy, proton beam therapy and, for diffuse cases, enucleation.1–3
A radioactive plaque is placed directly over the cornea, but this irradiation may damage the limbal stem cells or corneal epithelial cells, which may lead to ocular surface disease, including dry-eye problems.4 5 Such problems have been reported after the treatment of uveal melanomas with plaque therapy, proton beam radiotherapy and stereotactic radiotherapy.6–8 We determined whether treatment of anterior melanoma with Ruthenium-106 plaque therapy induced complaints and clinical signs of dry eyes.
Materials and methods
Between 1997 and August 2008, a total of 39 patients with iris and/or anterior ciliary body melanomas were treated with Ru-106 radiation therapy at the LUMC; 23 patients were seen for follow-up …
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