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Corneal collagen crosslinking in post-LASIK keratectasia
  1. J P Salgado,
  2. R Khoramnia,
  3. C P Lohmann,
  4. C Winkler von Mohrenfels
  1. Augenklinik Klinikum rechts der Isar, Technische Universität, Munich, Germany
  1. Correspondence to Dr Josefina P Salgado, Augenklinik, Technische Universität München, Ismaningerstr 22, 81675, Munich, Germany; josefina.salgado{at}


Background/aims To evaluate the effect of corneal collagen crosslinking with riboflavin and UV-A as a treatment option for postlaser in situ keratomileusis keratectasia.

Methods Crosslinking was carried out in 22 eyes of 15 patients with iatrogenic keratectasia. Follow-up, according to a standardised protocol (uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), slit-lamp examination, pachymetry and topography), was performed preoperatively 1, 3, 6 and 12 months after crosslinking.

Results The mean BCVA was 0.19 (SD±0.21) logMAR preoperatively, 0.25 (SD±0.17) 1 month, 0.20 (SD±0.20) 3 months, 0.18 (SD±0.21) 6 months and 0.15 (SD±0.14) 12 months postoperatively (statistically significant postop1–postop6, p=0.0335). The maximum k-readings were 44.12 (SD±3.97) preoperatively, 46.23 (SD±4.14) 1 month, 43.88 (SD±4.25) 3 months, 45.06 (SD±5.07) 6 months and 44.43 (SD±4.06) 12 months postoperatively (statistically significant preop–postop1, p=0.0281).

Conclusion Crosslinking in patients with iatrogenic keratectasia stabilised the UCVA and BCVA as well as the maximum k-readings in our cohort. It seems to be a safe and promising procedure to stabilise the refraction and the corneal topography, and thus to stop the progression of visual loss, thereby avoiding or delaying disease progression and keratoplasty.

  • Crosslinking
  • keratectasia
  • cornea

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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