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The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control
  1. Andrew J Treharne1,
  2. Martin C Grossel1,
  3. Andrew J Lotery2,3,
  4. Heather A Thomson2
  1. 1School of Chemistry, University of Southampton, Southampton, UK
  2. 2Clinical Neurosciences Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
  3. 3Southampton Eye Unit, Southampton General Hospital, Southampton, UK
  1. Correspondence to Professor Andrew J Lotery, Clinical Neurosciences Division, Mailpoint 806, Southampton General Hospital, Southampton SO16 6YD, UK; a.j.lotery{at}soton.ac.uk

Abstract

Age-related macular degeneration is the most common cause of blindness in the UK. Cellular replacement of retinal pigment epithelium cells is a potential therapeutic option to treat the cellular loss and dysfunction which is characteristic of age-related macular degeneration and other progressive retinopathies. A supportive scaffold, natural or artificial, may be required to facilitate cell delivery to the eye. Research to improve the biomimetic properties of such scaffolds, in order to optimise cell attachment and functionality following implantation, is ongoing. This short review will focus on the potential of biomaterials for ocular tissue engineering and how surface modification and the physical properties of these scaffolds can be tailored to help realise the full clinical potential of retinal pigment epithelium cell transplantation.

  • Retinal pigment epithelium
  • transplantation
  • retinal degeneration
  • biomaterials
  • cell adhesion
  • retina
  • macula
  • treatment other
  • Accepted 29 June 2010

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Footnotes

  • Funding Financial support was provided by the National Institute for Health Research, National Eye Research Centre, British Retinitis Pigmentosa Society and Foresight RP.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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