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Laboratory science
Does β-catenin have a role in pathogenesis of sebaceous cell carcinoma of the eyelid?
  1. Perumal Jayaraj1,
  2. Seema Sen1,
  3. Seema Kashyap1,
  4. Anjana Sharma2,
  5. Neelam Pushker3,
  6. Mandeep Singh Bajaj3,
  7. Supriyo Ghose3,
  8. Kunzang Chosdol4
  1. 1Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
  2. 2Department of Microbiology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
  3. 3Ophthalmoplasty Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
  4. 4Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
  1. Correspondence to Dr Seema Sen, Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; ssenop{at}rediffmail.com

Abstract

Aim Expression of β-catenin in sebaceous cell carcinoma (SbCC) of the eyelid and its correlation with histopathological features.

Method 48 cases of SbCC were analysed immunohistochemically using monoclonal β-catenin antibody and the results correlated with tumour size, histopathological differentiation, orbital invasion and pagetoid spread.

Resuts Cytoplasmic overexpression of β-catenin was seen in 66% cases of SbCC which correlated positively with tumour size, orbital invasion and pagetoid spread. This correlation was found to be significant in tumour size >2 cm (p=0.242). Nuclear staining was not observed in any of the cases.

Conclusion Cytoplasmic overexpression of β-catenin was observed in the majority of the cases of SbCC of eyelid, and this correlated significantly with tumour size. The authors therefore hypothesise that β-catenin overexpression in SbCC of eyelid may be a result of Wnt/β-catenin pathway dysregulation. However, its role both in the development of sebaceous cell carcinoma of the eyelid as well as its prognosis needs to be explored further.

  • Eyelid
  • sebaceous cell carcinoma
  • β-catenin
  • Immunohistochemistry
  • Wnt/β-catenin signalling pathway
  • pathology
  • neoplasia
  • Accepted 13 June 2010

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Footnotes

  • Funding Council of Scientific and Industrial Research (CSIR), Delhi.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the Institute Ethics Committee, AIIMS, New Delhi, India.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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