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Investigation of the potential of polymer therapeutics in corneal re-epithelialisation
  1. J Hardwicke,
  2. B Song,
  3. R Moseley,
  4. D W Thomas
  1. Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair (CITER), Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff, UK
  1. Correspondence to J Hardwicke, Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair (CITER), Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UK; hardwickej{at}doctors.org.uk

Abstract

In this study, the first use of a bioresponsive polymer therapeutic agent in the promotion of corneal re-epithelialisation after injury in an ex vivo whole-eye organ culture model was described. A polymer–protein conjugate consisting of dextrin and recombinant human epidermal growth factor was synthesised and applied as a single dose to a 2 mm ex vivo corneal ulcer, in culture. Enhanced wound healing was observed in response to dextrin–recombinant human epidermal growth factor, when exposed to α-amylase, compared with controls. This highlights the potential for polymer therapeutics to provide a platform for bioresponsive drug/protein delivery in the field of ophthalmology.

  • Cornea
  • wound healing
  • animal study
  • pharmacology
  • experimental animal models

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Footnotes

  • Funding JH was funded by a Fellowship from The Healing Foundation (Registered Charity No. 1078666) and the Welsh Office for Research and Development (WORD).

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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