In this study, the first use of a bioresponsive polymer therapeutic agent in the promotion of corneal re-epithelialisation after injury in an ex vivo whole-eye organ culture model was described. A polymer–protein conjugate consisting of dextrin and recombinant human epidermal growth factor was synthesised and applied as a single dose to a 2 mm ex vivo corneal ulcer, in culture. Enhanced wound healing was observed in response to dextrin–recombinant human epidermal growth factor, when exposed to α-amylase, compared with controls. This highlights the potential for polymer therapeutics to provide a platform for bioresponsive drug/protein delivery in the field of ophthalmology.
- wound healing
- animal study
- experimental animal models
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Funding JH was funded by a Fellowship from The Healing Foundation (Registered Charity No. 1078666) and the Welsh Office for Research and Development (WORD).
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.