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Aqueous humour penetration of moxifloxocin and gatifloxacin eye drops in different dosing regimens before phacoemulsification surgery
  1. Sirel Gür Güngör1,2,
  2. Yonca Aydin Akova1,
  3. Atila Bozkurt3,
  4. Ümit Yaşar3,
  5. Melih Ö Babaoğlu3,
  6. Altuğ Çetinkaya1,
  7. Meriç Çolak4
  1. 1Department of Ophthalmology, Başkent University, Faculty of Medicine, Ankara, Turkey
  2. 2Çankırı State Hospital Eye Clinic, Çankırı, Turkey
  3. 3Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
  4. 4Health Care Management, Başkent University Faculty of Medicine, Ankara, Turkey
  1. Correspondence to Dr Yonca Aydın Akova, Başkent University Faculty of Medicine, Fevzi Çakmak Caddesi, 06490, Bahçelievler, Ankara, Turkey; yoncaakova{at}yahoo.com

Abstract

Aim To compare the aqueous humour penetration of moxifloxacin 0.5% and gatifloxacin 0.3% eye drops administered in two different dosing regimens during phacoemulsification surgery.

Methods This prospective, randomised study included 97 patients. The patients were randomly divided into two treatment groups to receive either moxifloxacin or gatifloxacin. All patients received the topical antibiotics four times per day for 2 days prior to surgery. Patients in each group were further subdivided to receive additional doses of antibiotic drops as two drops 30 min apart (subgroup 1) versus four drops 10 min apart (subgroup 2) 1 h prior to the surgery. At the beginning of surgery, 0.1 ml of aqueous humour was aspirated, and the concentrations of moxifloxacin and gatifloxacin were analysed by high-performance liquid chromatography.

Results The mean concentrations of moxifloxacin and gatifloxacin in the aqueous humour were 0.72±0.40 μg/ml and 0.47±0.29 μg/ml, respectively, in the first subgroup, and 1.95±1.05 μg/ml and 0.77±0.52 μg/ml, respectively, in the second subgroup. Both the inter-group (p=0.006 and p=0.000, respectively) and the intra-group (p=0.000 and p=0.035, respectively) differences between the aqueous humour concentrations of moxifloxacin and gatifloxacin subgroups were statistically significant.

Conclusion Moxifloxacin, given in the same dosage, penetrated the aqueous humour better then gatifloxacin during cataract surgery. The penetration of both antibiotics increased significantly when the dosage of the agent was doubled.

  • Aqueous humour
  • gatifloxacin
  • moxifloxacin
  • phacoemulsification
  • pharmacology
  • treatment surgery
  • treatment medical

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Footnotes

  • This study was presented at the ASCRS Symposium on Cataract, IOL and Refractive Surgery, San Francisco, USA, April 2009.

  • Funding This study was supported by a grant from the Scientific and Technical Research Council of Turkey (SBAG-COST B25-105S027). M O B is the recipient of the Turkish Academy of Sciences, Young Scientist Award (MOB/TUBA-GEBIP/2007-06). This study was supported by an unrestricted grant from Alcon Laboratories, Inc. (Fort Worth, Texas, USA) and Allergan Inc., (Irvine, California, USA).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Institutional Review Board/Ethics Committee at the Baþkent University, Faculty of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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