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Detection of early functional changes in diabetic retina using slow double-stimulation mfERG paradigm
  1. Henry Ho-lung Chan,
  2. Patrick Ho-wai Chu,
  3. Jenny Chun-yee Lung,
  4. Wing-cheung Ho,
  5. Patrick Wai-ki Ting,
  6. Rita Wing-man Sum,
  7. Yiu-fai Ng
  1. Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, PR China
  1. Correspondence to Dr Henry H L Chan, School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, PR China; henryhl.chan{at}polyu.edu.hk

Abstract

Aim Diabetes mellitus (DM) is a systemic disease with insufficient secretion of insulin or poor response to insulin. This typically causes poor control of blood glucose level leading to a range of complications. Early detection of the retinal function alteration in DM is needed.

Methods A newly modified paradigm—slow double-stimulation multifocal electroretinogram (mfERG)—was introduced to measure early changes of retinal function in DM and to investigate changes in the adaptation mechanisms in the diabetic retina. The mfERG was measured by using a slow double-stimulation mfERG paradigm (M1M2OOO).

Results The m1 amplitude of M1 stimulation from diabetic subjects was significantly reduced in ring 1 in contrast to that of a control group. The m2 amplitude of M2 stimulation from diabetic subjects was also significantly reduced in ring 1 and 2 as compared with those of the control group. The m1/m2 ratio which minimises intersubject variation shows a reasonable differentiation between the control and diabetic groups. There was a significant increase in the amplitude ratio from diabetic subjects in ring 2 and 3 as compared with those of the control group.

Conclusions The present findings suggest that the new mfERG paradigm is a fast and sensitive test for the detection of early functional changes in the diabetic retina.

  • Retina
  • electrophysiology
  • physiology
  • diagnostic tests/investigation

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Footnotes

  • Parts of the data in this study were presented at the 47th ISCEV meeting in Padua, Abano-Terme, Italy in July 2009.

  • Funding General Research Fund (PolyU 5415/06M) from The Research Grants Committee of The Hong Kong SAR, the Niche Areas—Glaucoma Research (J-BB76) from The Hong Kong Polytechnic University.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the Ethics Committee of The Hong Kong Polytechnic University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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