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Association of high metabolic activity measured by positron emission tomography imaging with poor prognosis of choroidal melanoma
  1. Christopher Seungkyu Lee1,
  2. Arthur Cho2,
  3. Kyu Sung Lee1,
  4. Sung Chul Lee1
  1. 1Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea
  2. 2Department of Diagnostic Radiology, Division of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Korea
  1. Correspondence to Dr Sung Chul Lee, Department of Ophthalmology, Yonsei University College of Medicine, Sodaemungu Shinchondong 134, Seoul 120-752, Korea; sunglee{at}yuhs.ac

Abstract

Aims To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma.

Methods We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients.

Results SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression).

Conclusion Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.

  • Neoplasia
  • uveal melanoma
  • PET/CT
  • SUV
  • imaging
  • neoplasia

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Footnotes

  • Presented in part at the World Molecular Imaging Conference, 8–11 September 2010, Kyoto, Japan.

  • Funding This work was supported by a National Research Foundation of Korea Grant funded by the Korean Government (2009-0077504).

  • Competing interests None declared.

  • Ethics approval This study was conducted with the approval of the Yonsei University College of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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