Aims To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on 18F-labelled fluorodeoxyglucose positron emission tomography (18F-FDG-PET).
Methods Retrospective study of 54 consecutive patients with chronic uveitis for whom a PET scan was done because of suspected sarcoidosis, between July 2004 and December 2009. All the patients underwent a clinical examination, biological tests and a high-resolution CT of the chest.
Results 17 of the 54 patients (31.5%) presented hypermetabolic foci on 18F-FDG-PET scan consistent with sarcoidosis. Among them eight patients (14.8%) underwent biopsy showing non-caseating granuloma. At the end of the study, 10 patients (18.5%) were considered as having a presumed sarcoidosis and seven patients (12.9%) as having indeterminate sarcoidosis. The increasing age at the diagnosis of uveitis (p=0.01), the presence of posterior synechiae (p=0.01) and a positive high-resolution CT of the chest (p=0.01) were significantly related to an abnormal PET scan.
Conclusions Increasing age at the diagnosis of uveitis, the presence of posterior synechiae and the positivity of high-resolution chest CT are associated with 18F-FDG PET scan signs consistent with sarcoidosis.
- Uveitis, sarcoidosis
- PET scan
- fluorine-18 fluorodeoxyglucose positron emission tomography
- diagnostic tests/investigation
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Study performed at Hospices Civils de Lyon, Quai des Célestins, 69288 Lyon Cedex 02, France.
Competing interests None
Ethics approval This study was conducted with the approval of the Ethical Review Board of the University of Lyon.
Provenance and peer review Not commissioned; externally peer reviewed.