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Intraocular sarcoidosis: association of clinical characteristics of uveitis with findings from 18F-labelled fluorodeoxyglucose positron emission tomography
  1. Ahmed Rahmi1,5,
  2. Emmanuel Deshayes2,
  3. Delphine Maucort-Boulch3,5,
  4. Loig Varron4,5,
  5. Jean Daniel Grange1,5,
  6. Laurent Kodjikian1,5,
  7. Pascal Seve4,5
  1. 1Department of Ophthalmology, Hôpital Croix-Rousse, 103 Grande Rue de la Croix-Rousse, Lyon, France
  2. 2Department of Nuclear Medicine, Hôpital Edouard Herriot, Place d'Arsonval, 69437 Lyon, France
  3. 3Laboratoire Biostatistique Santé, Centre Hospitalier Lyon-Sud, Pierre-Bénite, Lyon, France
  4. 4Department of Internal Medicine, Hôpital Croix-Rousse, 103 Grande Rue de la Croix-Rousse, 69317 Lyon Cedex 04, France
  5. 5Université Claude Bernard Lyon 1, 43 Boulevard 11 Novembre 1918, Villeurbanne, France
  1. Correspondence to Pascal Sève, Department of Internal Medicine, Hôtel Dieu, 1 place de l'Hôpital, 69288 Lyon Cedex 02, France; pascal.seve{at}chu-lyon.fr

Abstract

Aims To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on 18F-labelled fluorodeoxyglucose positron emission tomography (18F-FDG-PET).

Methods Retrospective study of 54 consecutive patients with chronic uveitis for whom a PET scan was done because of suspected sarcoidosis, between July 2004 and December 2009. All the patients underwent a clinical examination, biological tests and a high-resolution CT of the chest.

Results 17 of the 54 patients (31.5%) presented hypermetabolic foci on 18F-FDG-PET scan consistent with sarcoidosis. Among them eight patients (14.8%) underwent biopsy showing non-caseating granuloma. At the end of the study, 10 patients (18.5%) were considered as having a presumed sarcoidosis and seven patients (12.9%) as having indeterminate sarcoidosis. The increasing age at the diagnosis of uveitis (p=0.01), the presence of posterior synechiae (p=0.01) and a positive high-resolution CT of the chest (p=0.01) were significantly related to an abnormal PET scan.

Conclusions Increasing age at the diagnosis of uveitis, the presence of posterior synechiae and the positivity of high-resolution chest CT are associated with 18F-FDG PET scan signs consistent with sarcoidosis.

  • Uveitis, sarcoidosis
  • PET scan
  • fluorine-18 fluorodeoxyglucose positron emission tomography
  • inflammation
  • diagnostic tests/investigation

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Footnotes

  • Study performed at Hospices Civils de Lyon, Quai des Célestins, 69288 Lyon Cedex 02, France.

  • Competing interests None

  • Ethics approval This study was conducted with the approval of the Ethical Review Board of the University of Lyon.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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