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Br J Ophthalmol doi:10.1136/bjophthalmol-2011-300476
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Is high-resolution spectral domain optical coherence tomography reliable in nystagmus?

  1. Irene Gottlob1
  1. 1Ophthalmology group, School of Medicine, University of Leicester, Leicester, UK
  2. 2Department of Health Sciences, University of Leicester, Leicester, UK
  3. 3Centre for Core Biotechnology Services, University of Leicester, UK
  1. Correspondence to Professor Irene Gottlob, Ophthalmology group, School of Medicine, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK; ig15{at}le.ac.uk

  1. Contributors MGT and IG were involved in the design and conduct of the study. MGT and AK performed data collection. Data analysis was done by MGT, AK, JRT and KS. Data interpretation was done by MGT, JRT, FAP and IG. Preparation of the first draft of the manuscript was done by MGT, and review and approval of the manuscript were performed by AK, JRT, FAP and IG.

  • Accepted 7 August 2011
  • Published Online First 27 September 2011

Recently, there has been an increased number of studies investigating retinal morphology in infantile nystagmus.1–4 Optical coherence tomography (OCT) studies in achromatopsia have shown progressive retinal changes.1 2 4 Most OCT software limits segmentation to the retinal nerve fibre layer and overall retinal thickness (RT). However, we have shown that outer nuclear layer (ONL), outer segment (OS) and foveal depth (FD) are important measurements in infantile nystagmus.2 5 Intraretinal thicknesses (FD, ONL, inner segment (IS) and OS) can be derived using reflectivity-based segmentation using ImageJ1 (figure 1). External limiting membrane (ELM) and inner–outer segment junction (IS/OS) reflectivity changes have been reported in blue cone monochromatism and achromatopsia. However, it is unclear whether nystagmus allows reproducible OCT measurements …

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