Br J Ophthalmol doi:10.1136/bjophthalmol-2011-300872
  • PostScript
  • Letter

Brimonidine (Alphagan) associated anterior uveitis

  1. William H Morgan1
  1. 1Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia
  2. 2St John of God Hospital, Subiaco, Western Australia, Australia
  1. Correspondence to Dr Josephine C Richards, Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia; diastella{at}
  1. Contributors CMM collected the data from patient files, drafted and revised the paper. JCR identified and managed the patients, planned the paper and revised the draft. DD identified and managed the patients and provided advice during the writing process. WHM provided advice during the planning and writing process.

  • Accepted 26 November 2011
  • Published Online First 18 January 2012

Brimonidine is a well-recognised cause of ocular surface disease but is less widely known to cause uveitis. We present important clinical lessons from five new cases of brimonidine-associated anterior uveitis.

Case reports

1. A 64-year-old man with primary open-angle glaucoma presented with red eyes and visual halos. He had used brimonidine 0.2%, timolol 0.5% and bimatoprost 0.03% for 13 months. There was bilateral anterior chamber inflammation with diffuse pigmented and stellate keratic precipitates. His intraocular pressure was 21 mm Hg bilaterally, rising to 26 mm Hg 3 weeks later. A …

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