Br J Ophthalmol doi:10.1136/bjophthalmol-2011-300996
  • Innovations

Use of iris recognition camera technology for the quantification of corneal opacification in mucopolysaccharidoses

  1. Jane Ashworth1,2
  1. 1Manchester Royal Eye Hospital, Manchester, UK
  2. 2The University of Manchester, Manchester Academic Health Sciences Centre, Oxford Road, Manchester, UK
  1. Correspondence to Dr Tariq Mehmood Aslam, Manchester Royal Eye Hospital, Oxford Road, Manchester M13 9WL, UK; vtariq.aslam{at}
  1. Contributors TA, JA and LA were involved in design and conception of the study. TA acquired and set up the iris camera and designed and wrote image analysis software. SS and JW coordinated imaging and imaging improvements.

  • Accepted 12 February 2012
  • Published Online First 6 March 2012


Mucopolysaccharidoses (MPS) can cause corneal opacification that is currently difficult to objectively quantify. With newer treatments for MPS comes an increased need for a more objective, valid and reliable index of disease severity for clinical and research use. Clinical evaluation by slit lamp is very subjective and techniques based on colour photography are difficult to standardise. In this article the authors present evidence for the utility of dedicated image analysis algorithms applied to images obtained by a highly sophisticated iris recognition camera that is small, manoeuvrable and adapted to achieve rapid, reliable and standardised objective imaging in a wide variety of patients while minimising artefactual interference in image quality.


  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by NRES UK.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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