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Br J Ophthalmol doi:10.1136/bjophthalmol-2011-301135
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Epithelial ingrowth cells after LASIK/ALTK (automated lamellar therapeutic keratoplasty): are they corneal epithelial stem cells?

  1. François Majo1
  1. 1Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland
  2. 2Laboratory of Neuropathology, Centre Hospitalier Universitaire, University of Liège, Liège, Belgium
  3. 3Division of Ophthalmology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland
  4. 4Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Dr François Majo, Jules-Gonin Eye Hospital, 15 Avenue de France, 1004 Lausanne, Switzerland; fmajo{at}bluewin.ch

  1. Contributors MN, HA, MD and FM Conception, design, acquisition of data, analysis and interpretation of data. Drafting the article, or revising it critically for important intellectual content. Final approval of the version to be published. FH, FLM and ZV Acquisition of data, analysis and interpretation of data. Final approval of the version to be published.

Epithelial ingrowth (EI) is a severe and incompletely understood complication after laser-assisted in situ keratomileusis (LASIK). Its incidence is variable and cases requiring surgical removal occur with a frequency of 0.92%–2.2%.1 2 Here, we report the clinical, morphological and immunohistological features of EI cells of four patients, two LASIKs, one FemtoLASIK and one ALTK, with EI that needed surgical removal (figure 1A). Immunohistochemistry was performed using antibodies against CK3, Muc5AC, CK15 and CK19 (differentiation markers) and against p63, BMI1, C/EBP δ and BCRP/ABCG2 (stem cell markers) and Ki67 (proliferation marker).3

Figure 1

Slit lamp images of the patients, histopathology and immunostaining of epithelial ingrowth (EI) specimens. (A) Case 1 underwent a Femtolaser-assisted in situ keratomileusis (FemtoLASIK) procedure for hyperopia, cases 2 and 4 a LASIK for myopia and hyperopia, respectively, and case 3 had an automated lamellar therapeutic …

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