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We read with great interest the editorial ‘Loss of reactivity in intravitreal anti-VEGF therapy: tachyphylaxis or tolerance?’ published recently in the British Journal of Ophthalmology.1 The editorial discussed possible mechanisms behind decreased anti-vascular endothelial growth factor (anti-VEGF) response to neovascular age-related macular degeneration (AMD). Two articles were published in the same issue in which tachyphylaxis was suggested to occur during anti-VEGF treatment of wet AMD.2 3 The editorial and these papers stimulated us to comment on the discussion. …
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